HORDB

ID: hor000493
Uniprot ID: A0A8J5JRR7
Protein name: Allatostatin A
Gene name: AstA-L1
Organism: Homarus americanus (American lobster)
Family: Allatostatin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007165 signal transduction
GO CC: NA

Sequence: SGPYSFGL
Length: 8(472-479)
Propeptide: MVGEHGGLGTCVLVVVVLLLTTTTTTAHDYLEDLDDPDTSRLLDVLQYYDTEPSYLYDYGKRHSNYGFGLGKRTPGYAFGLGKREGLYSLGLDKRSDLYSFGLGKKSGSYNFGLGKRSVGDLPEVSKVEDGASPRTKRDVSITEDTLEDKRAKYSFGIGKRESSKNKRSKLYGFGLGKRDSGEERREDDDMENRTQQYSFGLGKQDPDMEIEKRPRNYAFGLGKRESDEDSDKRSQMYSFGLGKRDPDMDMDKRP
Signal peptide: MVGEHGGLGTCVLVVVVLLLTTTTTTA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000493_AF2.pdb

hor000493_ESM.pdb

Mass:	95193	Formula:	C39H54N8O12
Absent amino acids:	ACDEHIKMNQRTVW	Common amino acids:	GS
pI:	6.09	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	16.25	Boman Index:	284
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	875	Extinction Coefficient cystines:	1490
Absorbance 280nm:	212.86

PubMed ID: 18304551
Title: Mass Spectral Characterization of Peptide Transmitters/Hormones in the Nervous System and Neuroendocrine Organs of the American Lobster Homarus Americanus